Metanephric mesenchymal cell differentiation

Across TCGA patient cohorts, RNA activity of the Metanephric mesenchymal cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2, KANK2, and AOC3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric mesenchymal cell differentiation activity versus SYNPO2 in UCEC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO2 →	-1.023	-0.189	<.001	<.001	3	9
UCEC	KANK2 →	-0.510	-0.133	<.001	<.001	3	9
BRCA	AOC3 →	-0.756	-0.106	<.001	<.001	3	9
CCRCC	NID1 →	-0.380	-0.116	<.001	<.001	3	9
GBM	STAT1 →	+0.593	+0.139	<.001	<.001	3	9
LSCC	TAP1 →	+0.584	+0.112	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072162 vs SYNPO2 — UCEC

Explore this scatter interactively →