Metanephric mesenchymal cell differentiation

Across TCGA patient cohorts, RNA activity of the Metanephric mesenchymal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL12RB1, LINC02099, and AIM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric mesenchymal cell differentiation activity versus IL12RB1 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IL12RB1 →	+0.572	+0.698	.001	<.001	3	6
LUAD	LINC02099 →	+0.161	+0.489	.005	.001	3	5
LSCC	AIM2 →	+1.234	+0.750	<.001	<.001	3	4
LSCC	ADGRE5 →	+0.697	+0.584	<.001	.002	3	4
LSCC	GZMA →	+0.872	+0.767	.001	<.001	3	4
LSCC	CD7 →	+0.600	+0.707	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072162 vs IL12RB1 — LSCC

Explore this scatter interactively →