Nephron tubule formation

Across TCGA cell cohorts, RNA activity of the Nephron tubule formation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJA2, PEX11G, and C10orf95, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJA2 grouped by Nephron tubule formation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNAJA2 →	+0.679	+0.332	.006	.001	3	3
BLOOD_Leukemia	PEX11G →	+0.748	+0.544	.001	.002	3	3
BLOOD_Lymphoma	C10orf95 →	-0.845	-1.593	<.001	.009	3	3
BLOOD_Myeloma	SURF1 →	-0.854	-1.712	.009	.002	3	3
BLOOD_Myeloma	PUS1 →	-0.920	-1.732	.009	.002	3	3
LIVER	ZNF287 →	+1.283	+1.095	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJA2 by Nephron tubule formation activity — OESOPHAGUS

Explore this box plot interactively →