Distal convoluted tubule development

pathway activity — cross-omics
GO:0072025Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Distal convoluted tubule development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TP53RK_T8, CARNMT1, and CEP57_S53, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Distal convoluted tubule development activity versus TP53RK_T8 in OV (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVTP53RK_T8 →-1.269-0.797<.001<.00132
OVCARNMT1 →+0.971+1.118<.001<.00132
OVCEP57_S53 →+0.769+0.759<.001<.00132
OVCFAP97_S330 →+0.580+0.750<.001<.00132
OVCGN_S120 →+1.470+1.156.001<.00132
OVCRTC3_S396 →+1.004+1.045<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072025 vs TP53RK_T8 — OV

Per-sample scatter of Distal convoluted tubule development activity vs TP53RK_T8 in OV.

Explore this scatter interactively →

Exploration