Distal convoluted tubule development

Across TCGA cell cohorts, RNA activity of the Distal convoluted tubule development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCG, RTKN2, and MAGED1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FANCG grouped by Distal convoluted tubule development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FANCG →	-0.672	-1.289	.008	.006	2	6
LIVER	RTKN2 →	-1.641	-1.320	.001	.002	3	4
LUNG_NSCLC_LUAD	MAGED1 →	+0.928	+0.673	<.001	.004	3	4
LUNG_SCLC	TMEM150A →	+1.446	+1.247	.005	.006	3	4
BLOOD_Leukemia	WASF1 →	-2.274	-1.204	.002	.004	3	4
BLOOD_Leukemia	HAVCR1 →	+0.053	+0.988	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FANCG by Distal convoluted tubule development activity — STOMACH

Explore this box plot interactively →