Adrenergic receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adrenergic receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIOX1, CNNM4, and ZDHHC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RIOX1 grouped by Adrenergic receptor signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RIOX1 →	+1.458	+0.927	.001	.004	3	5
PANCREAS	CNNM4 →	+0.527	+1.042	.005	<.001	3	5
SOFT_TISSUE	ZDHHC2 →	-2.017	-1.585	.001	<.001	3	4
SOFT_TISSUE	KPNA1 →	-0.882	-1.361	.004	.001	3	4
BONE	ZMAT3 →	-1.468	-1.089	<.001	.003	3	4
BONE	KTN1 →	-1.445	-1.530	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RIOX1 by Adrenergic receptor signaling pathway activity — CNS

Explore this box plot interactively →