Regulation of cell proliferation in bone marrow

Across TCGA cell cohorts, RNA activity of the Regulation of cell proliferation in bone marrow pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSFX4, CDK5RAP3, and LIMD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSFX4 grouped by Regulation of cell proliferation in bone marrow-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HSFX4 →	+0.142	+1.380	.001	.006	3	4
LARGE_INTESTINE	CDK5RAP3 →	+0.683	+0.958	.006	.006	3	4
STOMACH	LIMD1 →	-0.861	-1.214	<.001	.001	2	5
KIDNEY	MASP2 →	+0.330	+1.036	.004	.006	3	4
BLOOD_Leukemia	MBOAT1 →	+1.182	+0.699	.004	.003	3	4
SKIN	DMXL2 →	+0.698	+0.829	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSFX4 by Regulation of cell proliferation in bone marrow activity — LUNG_SCLC

Explore this box plot interactively →