Regulation of cell proliferation in bone marrow

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cell proliferation in bone marrow pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Regulation of cell proliferation in bone marrow pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD and LUAD, show the opposite pattern, with higher activity associated with better survival.

SCLC, ACC, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.336	0.631	<.001	66	view →
ACC	DFS	Median	All	0.440	0.718	.004	40	view →
READ	DFS	Median	All	0.399	0.670	.002	29	view →
LIHC	OS	Median	III,IV	0.343	0.620	.005	23	view →
KIRC	DFS	Quartile	IV	0.305	0.727	.003	18	view →
COAD	OS	Median	II,III,IV	0.878	0.709	.009	17	view →
LUAD	OS	Median	All	0.734	0.640	.005	17	view →
BRCA	OS	Quartile	III,IV	0.814	0.445	.002	16	view →
SKCM	DFS	Median	All	0.169	0.248	.011	16	view →
BLCA	DFS	Tertile	All	0.711	0.516	.027	14	view →
UVM	OS	Median	III,IV	1.000	0.324	.018	13	view →
KICH	DFS	Quartile	II,III,IV	1.000	0.534	.038	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0071863–SCLC (DFS)

Open the SCLC breakdown →