Triglyceride-rich lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Triglyceride-rich lipoprotein particle clearance pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN23, GNAI3, and DDX5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN23 grouped by Triglyceride-rich lipoprotein particle clearance-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PTPN23 →	-0.289	-0.789	<.001	.002	3	5
OVARY	GNAI3 →	+0.160	+0.954	.002	.003	3	5
URINARY_TRACT	DDX5 →	+0.309	+2.023	<.001	<.001	3	4
CNS	FGF22 →	+0.217	+1.132	.001	.003	3	4
SKIN	SCARB1 →	+0.172	+1.098	<.001	.001	3	4
BONE	MACROH2A1 →	+0.296	+1.365	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN23 by Triglyceride-rich lipoprotein particle clearance activity — BREAST

Explore this box plot interactively →