Triglyceride-rich lipoprotein particle clearance

Across TCGA pan-cancer cohorts, RNA activity of the Triglyceride-rich lipoprotein particle clearance pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Triglyceride-rich lipoprotein particle clearance pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and LGG, show the opposite pattern, with higher activity associated with better survival.

UVM, ACC, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.411	0.963	<.001	96	view →
ACC	OS	Median	All	0.782	0.950	<.001	92	view →
BRCA	OS	Median	All	0.948	0.903	.001	55	view →
LGG	DFS	Median	All	0.504	0.326	<.001	44	view →
SKCM	DFS	Tertile	All	0.420	0.153	.001	39	view →
BLCA	DFS	Quartile	All	0.527	0.721	.002	36	view →
DLBC	DFS	Median	All	0.606	1.000	.011	24	view →
KIRP	DFS	Tertile	II,III,IV	0.923	0.201	.008	20	view →
CESC	DFS	Quartile	IV	0.748	0.313	.023	18	view →
MESO	DFS	Tertile	II,III,IV	0.256	0.649	.010	18	view →
THYM	OS	Median	II,III,IV	0.918	1.000	.015	14	view →
LIHC	DFS	Tertile	All	0.526	0.353	.015	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0071830–UVM (DFS)

Open the UVM breakdown →