Protein-lipid complex organization

Across TCGA patient cohorts, RNA activity of the Protein-lipid complex organization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP10_S269, GPD1, and PBRM1_S1453, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-lipid complex organization activity versus CASP10_S269 in PDAC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CASP10_S269 →	+0.478	+0.039	.004	.002	3	5
BRCA	GPD1 →	+0.935	+0.024	.001	.004	3	5
LUAD	PBRM1_S1453 →	-0.734	-0.020	<.001	.008	3	4
CCRCC	CLINT1 →	+0.139	+0.034	<.001	.004	3	4
GBM	NHS →	+0.392	+0.047	.003	.001	3	4
GBM	PPCS →	+0.351	+0.047	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071825 vs CASP10_S269 — PDAC

Explore this scatter interactively →