Protein-lipid complex organization

Across TCGA patient cohorts, RNA activity of the Protein-lipid complex organization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3R5, CD163, and PLTP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-lipid complex organization activity versus PIK3R5 in LSCC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIK3R5 →	+0.782	+0.241	<.001	<.001	3	7
GBM	CD163 →	+1.480	+0.188	<.001	<.001	3	7
BRCA	PLTP →	+1.138	+0.266	<.001	<.001	3	7
HNSC	CXCL12 →	+1.316	+0.217	<.001	<.001	3	6
GBM	MS4A4A →	+1.057	+0.170	<.001	<.001	3	6
HNSC	WDFY4 →	+0.838	+0.197	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071825 vs PIK3R5 — LSCC

Explore this scatter interactively →