Protein-lipid complex organization

Across TCGA cell cohorts, RNA activity of the Protein-lipid complex organization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZER1, ZFAND6, and MAP2K5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-lipid complex organization activity versus ZER1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZER1 →	-1.017	-1.058	<.001	<.001	3	5
LUNG_SCLC	ZFAND6 →	-0.686	-0.953	.008	.009	3	5
BLOOD_Lymphoma	MAP2K5 →	-0.900	-0.880	.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	CHP1 →	-0.836	-1.104	<.001	<.001	3	5
LIVER	SMIM29 →	-1.847	-1.391	.002	.002	3	5
OESOPHAGUS	ZFP69B →	-1.101	-1.235	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071825 vs ZER1 — UPPER_AERODIGESTIVE_TRACT

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