Protein transmembrane transport

Across TCGA patient cohorts, RNA activity of the Protein transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HERC1, FILIP1, and PTPRB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transmembrane transport activity versus HERC1 in CCRCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HERC1 →	-0.225	-0.196	.005	.005	3	5
CCRCC	FILIP1 →	-0.845	-0.280	<.001	.001	3	5
CCRCC	PTPRB →	-0.728	-0.247	<.001	<.001	3	5
PDAC	ZNF280D →	-0.352	-0.150	.003	.007	3	5
BRCA	ZMYND11 →	-0.409	-0.123	.009	.009	3	5
UCEC	SPARCL1 →	-1.267	-0.180	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071806 vs HERC1 — CCRCC

Explore this scatter interactively →