Positive regulation of monocyte chemotactic protein-1 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of monocyte chemotactic protein-1 production pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC3, SPINK5, and N4BP3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of monocyte chemotactic protein-1 production activity versus RFC3 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RFC3 →	+1.680	+0.276	<.001	.002	3	3
OVARY	SPINK5 →	-2.846	-0.350	.003	.005	3	3
OVARY	N4BP3 →	-1.099	-0.350	.003	.005	3	3
OVARY	NPIPB4 →	-1.366	-0.350	.008	.005	3	3
OVARY	SLCO6A1 →	-0.660	-0.481	.003	<.001	3	3
LUNG_NSCLC_LUAD	RRP36 →	+0.877	+0.270	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071639 vs RFC3 — UPPER_AERODIGESTIVE_TRACT

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