Negative regulation of monocyte chemotactic protein-1 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of monocyte chemotactic protein-1 production pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOCS5, APOD, and DOCK1, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monocyte chemotactic protein-1 production activity versus SOCS5 in THYM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	SOCS5 →	+1.202	+0.067	<.001	<.001	3	28
DLBC	APOD →	+3.208	+0.052	.002	<.001	3	28
THYM	DOCK1 →	+1.479	+0.059	<.001	<.001	3	26
THYM	STARD13 →	+1.074	+0.069	<.001	<.001	3	25
THYM	SLC16A4 →	+1.801	+0.079	<.001	<.001	3	25
PAAD	AOC3 →	+1.425	+0.095	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071638 vs SOCS5 — THYM

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