Negative regulation of monocyte chemotactic protein-1 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of monocyte chemotactic protein-1 production pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS3, TLN2, and TPM1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monocyte chemotactic protein-1 production activity versus SORBS3 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SORBS3 →	+0.486	+0.076	<.001	.007	3	9
BRCA	TLN2 →	+0.773	+0.102	<.001	<.001	3	9
OV	TPM1 →	+0.590	+0.105	<.001	<.001	3	9
UCEC	CNRIP1 →	+0.785	+0.121	<.001	<.001	3	9
COAD	CSRP1 →	+0.924	+0.080	<.001	<.001	3	9
BRCA	DCN →	+1.061	+0.088	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071638 vs SORBS3 — UCEC

Explore this scatter interactively →