Negative regulation of monocyte chemotactic protein-1 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of monocyte chemotactic protein-1 production pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALKBH2, MAFG, and TXNRD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALKBH2 grouped by Negative regulation of monocyte chemotactic protein-1 production-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ALKBH2 →	+0.727	+1.395	.004	<.001	3	5
KIDNEY	MAFG →	-0.932	-0.999	.001	.001	3	4
KIDNEY	TXNRD1 →	-1.556	-1.338	<.001	<.001	3	4
LUNG_NSCLC_LUSC	CD2BP2 →	+0.617	+1.215	.002	.007	3	4
SKIN	RNF217 →	-0.370	-0.760	.009	.007	3	4
SOFT_TISSUE	UBE2E2 →	-2.751	-1.359	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALKBH2 by Negative regulation of monocyte chemotactic protein-1 production activity — SOFT_TISSUE

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