Vocalization behavior

Across TCGA patient cohorts, RNA activity of the Vocalization behavior pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIE1, TEK, and HSPA12B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vocalization behavior activity versus TIE1 in CCRCC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TIE1 →	+1.011	+0.476	<.001	<.001	3	8
CCRCC	TEK →	+1.229	+0.585	<.001	<.001	3	7
CCRCC	HSPA12B →	+0.952	+0.499	<.001	<.001	3	7
CCRCC	DIPK2B →	+1.047	+0.533	<.001	<.001	3	7
CCRCC	TAL1 →	+1.125	+0.591	<.001	<.001	3	7
CCRCC	CLEC14A →	+1.267	+0.516	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071625 vs TIE1 — CCRCC

Explore this scatter interactively →