Monocyte chemotactic protein-1 production

pathway activity — cross-omics
GO:0071605Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Monocyte chemotactic protein-1 production pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD99, PCYOX1, and ATOH8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMCD99 →+0.594+0.209<.001.00334
GBMPCYOX1 →+0.190+0.200.006.00533
CCRCCATOH8 →-1.071-0.480<.001.00333
CCRCCKRT18P22 →+0.152+0.472.004.00333
BRCASH3PXD2A →+0.821+0.243<.001<.00133
BRCAAAK1 →+0.391+0.199<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration