Lymphocyte aggregation

Across TCGA cell cohorts, RNA activity of the Lymphocyte aggregation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C10orf55, TFR2, and SLC26A11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte aggregation activity versus C10orf55 in BREAST (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C10orf55 →	+1.001	+0.321	.002	<.001	3	4
KIDNEY	TFR2 →	-1.037	-0.241	<.001	.007	3	4
KIDNEY	SLC26A11 →	-2.602	-0.245	.007	.003	3	4
OVARY	RIMS3 →	-1.691	-0.333	.005	.005	3	4
LUNG_NSCLC_LUAD	CAP1 →	+1.078	+0.311	.002	.001	3	3
LUNG_NSCLC_LUAD	HMGA1 →	+1.368	+0.318	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071593 vs C10orf55 — BREAST

Explore this scatter interactively →