Response to transforming growth factor beta

Across TCGA cell cohorts, RNA activity of the Response to transforming growth factor beta pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAMP3, SNX7, and ZG16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCAMP3 grouped by Response to transforming growth factor beta-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCAMP3 →	+0.776	+0.575	.004	.006	3	3
LUNG_NSCLC_LUAD	SNX7 →	+0.641	+0.362	.005	.001	3	3
LUNG_NSCLC_LUAD	ZG16 →	-0.177	-0.357	.009	.005	3	3
LUNG_NSCLC_LUAD	ANXA6 →	+2.621	+0.469	<.001	.003	3	3
LUNG_NSCLC_LUAD	TNFRSF25 →	-1.169	-0.340	<.001	.002	3	3
LUNG_NSCLC_LUAD	NTF4 →	-0.661	-0.295	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCAMP3 by Response to transforming growth factor beta activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →