Dopaminergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the Dopaminergic neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIC1_S237, SFRP2, and FSTL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopaminergic neuron differentiation activity versus HIC1_S237 in OV (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HIC1_S237 →	+0.826	+0.055	<.001	<.001	3	6
BRCA	SFRP2 →	+0.625	+0.036	.006	.001	3	6
LUAD	FSTL1 →	+0.436	+0.043	.002	.003	3	5
LSCC	FSTL1_S165 →	+0.930	+0.070	.002	.001	2	6
OV	VIM_S72 →	+1.809	+0.066	.001	.001	3	5
GBM	COL1A1 →	+0.861	+0.062	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071542 vs HIC1_S237 — OV

Explore this scatter interactively →