Semaphorin-plexin signaling pathway

Across TCGA cell cohorts, RNA activity of the Semaphorin-plexin signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJA3, IGHMBP2, and GTPBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJA3 grouped by Semaphorin-plexin signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DNAJA3 →	+0.378	+0.490	.001	.007	3	4
KIDNEY	IGHMBP2 →	+0.597	+1.206	.005	.001	3	4
BONE	GTPBP1 →	+0.866	+0.886	.009	.006	3	4
BONE	SF1 →	+0.863	+1.125	.008	.006	3	4
LUNG_NSCLC_LUSC	YIPF3 →	-0.573	-1.078	.005	<.001	3	3
LUNG_NSCLC_LUSC	PRXL2C →	-1.378	-1.406	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJA3 by Semaphorin-plexin signaling pathway activity — SKIN

Explore this box plot interactively →