Semaphorin-plexin signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Semaphorin-plexin signaling pathway pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 44 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Semaphorin-plexin signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRP, THCA, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.889	0.969	<.001	118	view →
THCA	OS	Median	III,IV	0.935	1.000	<.001	47	view →
UCS	DFS	Tertile	III,IV	0.576	0.100	<.001	44	view →
HNSC	DFS	Quartile	IV	0.499	0.255	.001	37	view →
ESCA	DFS	Median	III,IV	0.595	0.326	.003	27	view →
STAD	DFS	Quartile	All	0.351	0.575	.009	25	view →
LAML	DFS	Quartile	All	0.188	0.479	.010	24	view →
KIRC	DFS	Median	IV	0.223	0.419	.018	22	view →
BLCA	DFS	Median	All	0.402	0.281	.021	20	view →
LUSC	DFS	Tertile	III,IV	0.323	0.961	<.001	17	view →
UCEC	OS	Quartile	IV	0.791	0.263	.010	16	view →
CESC	DFS	Tertile	All	0.776	0.893	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0071526–KIRP (OS)

Open the KIRP breakdown →