Semaphorin-plexin signaling pathway

Across TCGA cell cohorts, RNA activity of the Semaphorin-plexin signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF430, PKN1, and GALNS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semaphorin-plexin signaling pathway activity versus ZNF430 in OESOPHAGUS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF430 →	+1.221	+0.285	.003	.001	2	7
LARGE_INTESTINE	PKN1 →	+1.152	+0.368	.002	<.001	3	5
SOFT_TISSUE	GALNS →	-1.155	-0.598	.001	.002	2	5
BONE	SH2B3 →	+2.108	+0.417	.001	.007	3	4
BONE	LRIG1 →	+2.245	+0.312	.002	.004	3	4
BLOOD_Lymphoma	MC1R →	-1.532	-0.163	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071526 vs ZNF430 — OESOPHAGUS

Explore this scatter interactively →