Cellular response to heparin

Across TCGA cell cohorts, RNA activity of the Cellular response to heparin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIPBL, CSRP1, and NISCH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NIPBL grouped by Cellular response to heparin-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NIPBL →	-0.740	-1.377	.003	.002	3	4
BLOOD_Lymphoma	CSRP1 →	+1.232	+1.693	.009	.005	3	4
LARGE_INTESTINE	NISCH →	-0.574	-0.799	.003	.009	3	4
LUNG_NSCLC_LUSC	ELFN2 →	+1.869	+0.880	<.001	.009	3	3
URINARY_TRACT	KCND1 →	+1.616	+2.020	.008	<.001	3	3
BREAST	KLHL12 →	-0.626	-0.811	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NIPBL by Cellular response to heparin activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →