"Protein localization to chromosome, centromeric region"

Across TCGA patient cohorts, RNA activity of the "Protein localization to chromosome, centromeric region" pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, RIF1_S782, and WDR43_S77, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Protein localization to chromosome, centromeric region" activity versus SMC2 in LUAD (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMC2 →	+0.735	+0.102	<.001	<.001	3	10
BRCA	RIF1_S782 →	+0.706	+0.058	<.001	<.001	3	9
UCEC	WDR43_S77 →	+0.654	+0.108	<.001	<.001	3	9
LSCC	LRWD1_S243 →	+1.111	+0.104	<.001	<.001	3	9
LSCC	MSH6 →	+0.785	+0.107	<.001	<.001	3	9
LUAD	ATAD2 →	+0.534	+0.067	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071459 vs SMC2 — LUAD

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