"Protein localization to chromosome, centromeric region"

Across TCGA pan-cancer cohorts, RNA activity of the "Protein localization to chromosome, centromeric region" pathway differs between tumor and matched normal tissue in 17 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

HNSC, BLCA, and STAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Male	IV	+0.083	<.001	12	view →
BLCA	Male	All	+0.135	<.001	11	view →
STAD	Female	All	+0.137	<.001	10	view →
COAD	All	III,IV	+0.051	<.001	10	view →
LUAD	Male	All	+0.131	<.001	9	view →
LIHC	Male	II,III,IV	+0.073	<.001	9	view →
LUSC	Male	III,IV	+0.170	<.001	8	view →
KIRP	All	III,IV	+0.042	.001	8	view →
KIRC	Male	II,III,IV	+0.027	<.001	7	view →
UCEC	All	III,IV	+0.130	<.001	6	view →
BRCA	All	II,III,IV	+0.105	<.001	6	view →
THCA	All	II,III,IV	+0.020	.004	5	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 17 lineages.

GO:0071459–HNSC

Open the HNSC breakdown →