"Protein localization to chromosome, centromeric region"

Across TCGA pan-cancer cohorts, RNA activity of the "Protein localization to chromosome, centromeric region" pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 39 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher "Protein localization to chromosome, centromeric region" pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THYM and OV, show the opposite pattern, with higher activity associated with better survival.

KIRP, ACC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.569	0.796	<.001	156	view →
ACC	OS	Median	All	0.303	0.837	<.001	143	view →
KIRC	DFS	Median	All	0.538	0.711	<.001	130	view →
KICH	DFS	Tertile	All	0.600	0.961	.001	99	view →
MESO	OS	Median	All	0.392	0.650	<.001	87	view →
LIHC	OS	Median	All	0.597	0.764	<.001	71	view →
UCEC	DFS	Median	All	0.578	0.715	.002	70	view →
UVM	DFS	Tertile	III,IV	0.217	1.000	.001	69	view →
LGG	OS	Median	All	0.701	0.892	<.001	54	view →
PAAD	OS	Quartile	All	0.191	0.624	<.001	46	view →
THCA	DFS	Median	All	0.909	0.970	.002	45	view →
LUAD	DFS	Tertile	All	0.749	0.874	<.001	36	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0071459–KIRP (OS)

Open the KIRP breakdown →