Cellular response to hydroperoxide

Across TCGA patient cohorts, RNA activity of the Cellular response to hydroperoxide pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, SMC4, and DBNL_T291, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to hydroperoxide activity versus RFC1_S368 in LSCC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC1_S368 →	-0.547	-0.430	<.001	<.001	3	4
LSCC	SMC4 →	-0.450	-0.514	<.001	<.001	3	4
LSCC	DBNL_T291 →	+1.029	+0.744	<.001	<.001	3	4
PDAC	AHNAK_S5857 →	+0.819	+0.564	<.001	<.001	3	4
LUAD	FAM76B_T215 →	-0.855	-0.672	<.001	<.001	3	4
LSCC	PRKD1_S249 →	+0.798	+0.622	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071447 vs RFC1_S368 — LSCC

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