Cellular response to fatty acid

Across TCGA patient cohorts, RNA activity of the Cellular response to fatty acid pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C2, ALDH1A1, and AKR1C3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to fatty acid activity versus AKR1C2 in LUAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKR1C2 →	+1.751	+0.079	<.001	<.001	3	8
BRCA	ALDH1A1 →	+0.761	+0.053	<.001	<.001	3	8
LSCC	AKR1C3 →	+1.141	+0.081	<.001	<.001	3	7
LUAD	IPO8 →	-0.207	-0.062	.007	<.001	3	7
BRCA	SIRT1_S47 →	-0.367	-0.036	.003	<.001	3	7
LSCC	RFC1 →	-0.319	-0.080	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071398 vs AKR1C2 — LUAD

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