Cellular response to fatty acid

Across TCGA patient cohorts, RNA activity of the Cellular response to fatty acid pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C2, EXOC6B, and IRS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to fatty acid activity versus AKR1C2 in CCRCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AKR1C2 →	+0.704	+0.331	.001	.001	3	6
GBM	EXOC6B →	+0.334	+0.720	.001	.002	3	5
BRCA	IRS1 →	+1.265	+0.480	<.001	.003	3	5
BRCA	PHYHIP →	+0.430	+0.538	.005	.001	3	5
UCEC	CFAP69 →	+0.704	+0.599	<.001	<.001	3	4
OV	PAM →	+0.870	+0.759	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071398 vs AKR1C2 — CCRCC

Explore this scatter interactively →