Cellular response to progesterone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to progesterone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-1065P, CORO1CP1, and CAPN3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to progesterone stimulus activity versus RNU6-1065P in BRCA (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-1065P →	-0.468	-0.538	.003	.001	3	3
BRCA	CORO1CP1 →	-0.051	-0.823	<.001	.001	3	3
BRCA	CAPN3 →	-0.284	-0.599	.009	.004	3	3
LSCC	TACR1 →	-0.598	-0.551	.003	.007	3	3
COAD	DPEP2 →	-0.299	-0.180	.007	.006	3	3
COAD	OR5BK1P →	-0.251	-0.192	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071393 vs RNU6-1065P — BRCA

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