Cellular response to estradiol stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to estradiol stimulus pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, ATP5F1B, and ANXA8L1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to estradiol stimulus activity versus ITGA2 in URINARY_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ITGA2 →	+2.680	+0.395	.001	.008	3	8
UPPER_AERODIGESTIVE_TRACT	ATP5F1B →	-0.948	-0.254	.001	<.001	3	7
OESOPHAGUS	ANXA8L1 →	+4.721	+0.369	<.001	.006	2	8
BREAST	ANXA8 →	+4.167	+0.196	<.001	.003	2	8
BREAST	LAMC2 →	+3.974	+0.207	<.001	.007	3	7
OESOPHAGUS	ADRB2 →	+2.215	+0.352	.009	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071392 vs ITGA2 — URINARY_TRACT

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