Cellular response to prostaglandin stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to prostaglandin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESCO1, DCDC2B, and CRY2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ESCO1 grouped by Cellular response to prostaglandin stimulus-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ESCO1 →	-0.822	-0.904	<.001	.001	3	5
LUNG_SCLC	DCDC2B →	-0.168	-0.766	.003	.001	3	3
LIVER	CRY2 →	-0.655	-1.007	.002	.001	3	3
OVARY	ZNF225 →	-0.407	-0.682	.008	.006	3	3
CNS	CLGN →	-2.430	-1.395	<.001	<.001	3	3
CNS	ZCCHC4 →	-0.571	-0.995	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ESCO1 by Cellular response to prostaglandin stimulus activity — OVARY

Explore this box plot interactively →