Cellular response to ether

Across TCGA patient cohorts, RNA activity of the Cellular response to ether pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRY2, DZIP1, and MIR145, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ether activity versus CRY2 in CCRCC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CRY2 →	-0.413	-0.149	.006	.002	3	5
HNSC	DZIP1 →	-0.946	-0.211	<.001	<.001	3	4
HNSC	MIR145 →	-1.173	-0.189	.002	.001	3	4
CCRCC	GPC6-AS1 →	-0.653	-0.137	<.001	.002	3	4
CCRCC	MIR3125 →	-0.659	-0.152	.004	.001	3	4
UCEC	ADGRL3 →	-1.263	-0.163	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071362 vs CRY2 — CCRCC

Explore this scatter interactively →