Cellular response to exogenous dsRNA

Across TCGA patient cohorts, RNA activity of the Cellular response to exogenous dsRNA pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFIH1, GBP1, and PARP9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to exogenous dsRNA activity versus IFIH1 in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IFIH1 →	+0.817	+0.238	<.001	.001	3	7
LSCC	GBP1 →	+0.939	+0.325	<.001	<.001	3	6
LSCC	PARP9 →	+0.771	+0.266	<.001	<.001	3	6
LSCC	OAS2 →	+0.879	+0.199	.003	.002	3	6
LSCC	SP110 →	+0.395	+0.228	<.001	<.001	3	6
BRCA	IFI44 →	+0.911	+0.166	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071360 vs IFIH1 — LSCC

Explore this scatter interactively →