Cellular response to exogenous dsRNA

Across TCGA pan-cancer cohorts, RNA activity of the Cellular response to exogenous dsRNA pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUAD and LUSC, show the opposite pattern, with lower activity in tumor tissue.

HNSC, KIRC, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Female	IV	+0.128	<.001	11	view →
KIRC	Female	All	+0.068	<.001	11	view →
LUAD	Female	III,IV	−0.095	<.001	8	view →
LUSC	Female	All	−0.082	<.001	7	view →
KIRP	All	All	−0.041	<.001	7	view →
UCEC	All	II,III,IV	−0.075	<.001	6	view →
BRCA	All	II,III,IV	−0.042	<.001	6	view →
COAD	Female	II,III,IV	−0.050	<.001	4	view →
KICH	All	All	−0.044	<.001	4	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0071360–HNSC

Open the HNSC breakdown →