Cellular response to alkaloid

Across TCGA cell cohorts, RNA activity of the Cellular response to alkaloid pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO5C, DBNDD1, and FAAP100, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYO5C grouped by Cellular response to alkaloid-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYO5C →	+2.054	+0.264	.002	<.001	3	4
BREAST	DBNDD1 →	+1.717	+0.264	<.001	.001	3	4
LIVER	FAAP100 →	+1.113	+0.277	.002	<.001	3	4
SOFT_TISSUE	CFL2 →	-1.056	-0.285	.008	.005	3	4
BLOOD_Leukemia	GNL3L →	-0.786	-0.249	.004	<.001	3	4
BLOOD_Leukemia	PRPS1 →	-0.745	-0.276	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYO5C by Cellular response to alkaloid activity — PANCREAS

Explore this box plot interactively →