Cellular response to cadmium ion

Across TCGA cell cohorts, RNA activity of the Cellular response to cadmium ion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMD, CNOT9, and NDUFAB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cadmium ion activity versus MMD in LIVER (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MMD →	+2.202	+0.363	.008	.002	3	5
LIVER	CNOT9 →	+0.525	+0.234	.009	.002	3	5
LIVER	NDUFAB1 →	+0.900	+0.369	.001	.002	3	5
LIVER	SETD1A →	+1.047	+0.355	.006	.004	3	4
LUNG_SCLC	WASF1 →	+1.154	+0.272	<.001	<.001	3	4
STOMACH	TUFT1 →	-0.984	-0.278	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071276 vs MMD — LIVER

Explore this scatter interactively →