Response to interleukin-9

Across TCGA cell cohorts, RNA activity of the Response to interleukin-9 pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1, STAT3, and PSMB1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-9 activity versus STAT1 in BLOOD_Myeloma (Pearson r = 0.98).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	STAT1 →	+4.829	+2.406	.001	<.001	3	18
BLOOD_Lymphoma	STAT3 →	+1.487	+1.321	.001	<.001	3	12
BREAST	PSMB1 →	+0.774	+1.200	<.001	<.001	3	8
BLOOD_Lymphoma	EIF2AK2 →	+1.356	+1.273	<.001	<.001	3	7
BLOOD_Lymphoma	WARS1 →	+1.297	+1.303	<.001	<.001	3	6
BREAST	ANXA7 →	+1.173	+1.187	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071104 vs STAT1 — BLOOD_Myeloma

Explore this scatter interactively →