Positive regulation of phospholipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of phospholipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN2, SLC35F6, and TGFB1I1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of phospholipid biosynthetic process activity versus CAPN2 in BLOOD_Lymphoma (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CAPN2 →	+3.712	+0.798	<.001	<.001	3	9
LUNG_NSCLC_LUSC	SLC35F6 →	+1.158	+0.307	.001	<.001	3	6
OESOPHAGUS	TGFB1I1 →	+3.047	+0.384	<.001	.002	3	6
BLOOD_Lymphoma	TNFRSF9 →	+2.671	+0.816	.001	.002	3	6
BLOOD_Lymphoma	HADHB →	+1.001	+1.112	<.001	<.001	3	5
LARGE_INTESTINE	DNAJB5 →	+0.672	+0.240	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071073 vs CAPN2 — BLOOD_Lymphoma

Explore this scatter interactively →