Error-free translesion synthesis

Across TCGA patient cohorts, RNA activity of the Error-free translesion synthesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GABARAPL2, C11orf58, and GALNT15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Error-free translesion synthesis activity versus GABARAPL2 in OV (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GABARAPL2 →	-0.522	-0.157	.001	.003	3	4
OV	C11orf58 →	-0.377	-0.155	.009	<.001	3	3
GBM	GALNT15 →	-1.035	-0.180	<.001	<.001	3	3
COAD	SYTL4 →	-0.479	-0.112	.009	.004	3	2
COAD	CHD5 →	-0.105	-0.129	.008	<.001	3	2
COAD	PLPBP →	-0.490	-0.150	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070987 vs GABARAPL2 — OV

Explore this scatter interactively →