Protein K11-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K11-linked ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, RRP36_S73, and TOP2A_S1247, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K11-linked ubiquitination activity versus RPL12_S38 in LUAD (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+1.100	+0.071	<.001	<.001	3	8
LUAD	RRP36_S73 →	+0.640	+0.054	<.001	<.001	3	8
LUAD	TOP2A_S1247 →	+1.271	+0.071	<.001	<.001	3	8
GBM	SMC2 →	+0.718	+0.073	<.001	<.001	3	7
GBM	SMC4 →	+0.682	+0.062	<.001	<.001	3	7
LUAD	TOP2A_S1106 →	+1.145	+0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070979 vs RPL12_S38 — LUAD

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