Bone maturation

Across TCGA cell cohorts, RNA activity of the Bone maturation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPSF4, SLC41A2, and WRN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone maturation activity versus CPSF4 in LIVER (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CPSF4 →	+0.708	+1.547	.004	<.001	3	6
LUNG_NSCLC_LUSC	SLC41A2 →	-2.440	-1.692	<.001	<.001	3	5
KIDNEY	WRN →	+0.960	+1.446	.005	<.001	3	4
CNS	SUGP1 →	+0.607	+0.928	<.001	.002	3	4
KIDNEY	HELB →	+0.590	+1.515	.009	<.001	3	4
KIDNEY	SERPINE2 →	-1.976	-1.566	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070977 vs CPSF4 — LIVER

Explore this scatter interactively →