Bone maturation

Across TCGA pan-cancer cohorts, RNA activity of the Bone maturation pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 28 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Bone maturation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LAML and UCS, show the opposite pattern, with higher activity associated with better survival.

MESO, THCA, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.287	0.489	.003	54	view →
THCA	OS	Quartile	II,III,IV	0.934	0.997	.003	36	view →
SCLC	DFS	Quartile	II,III,IV	0.224	0.712	.002	32	view →
LAML	DFS	Tertile	All	0.740	0.426	.016	28	view →
UCS	DFS	Tertile	III,IV	0.716	0.271	.006	26	view →
SARC	OS	Median	All	0.674	0.808	.001	24	view →
ACC	DFS	Median	All	0.543	0.762	.006	22	view →
KIRC	DFS	Quartile	All	0.950	0.868	.006	22	view →
HNSC	OS	Tertile	All	0.602	0.773	.011	13	view →
THYM	DFS	Quartile	All	1.000	0.688	.028	12	view →
SKCM	OS	Tertile	IV	0.809	0.350	.007	12	view →
STAD	OS	Median	II,III,IV	0.474	0.618	.027	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0070977–MESO (OS)

Open the MESO breakdown →