Neutrophil-mediated killing of symbiont cell

Across TCGA patient cohorts, RNA activity of the Neutrophil-mediated killing of symbiont cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A8, SP4_S46, and AZU1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil-mediated killing of symbiont cell activity versus S100A8 in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	S100A8 →	+1.445	+0.139	<.001	<.001	3	6
PDAC	SP4_S46 →	-0.523	-0.077	<.001	<.001	3	6
GBM	AZU1 →	+1.121	+0.105	<.001	.003	3	6
LSCC	GABPA →	-0.216	-0.103	<.001	<.001	3	6
GBM	MPO →	+0.908	+0.088	<.001	<.001	3	6
GBM	PSIP1 →	-0.612	-0.105	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070943 vs S100A8 — GBM

Explore this scatter interactively →