Neutrophil-mediated killing of symbiont cell

Across TCGA pan-cancer cohorts, RNA activity of the Neutrophil-mediated killing of symbiont cell pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Neutrophil-mediated killing of symbiont cell pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as OV and UVM, show the opposite pattern, with higher activity associated with better survival.

BRCA, KICH, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.709	0.870	<.001	92	view →
KICH	OS	Median	II,III,IV	0.533	0.965	<.001	55	view →
OV	OS	Median	IV	0.496	0.266	.005	42	view →
LGG	OS	Median	All	0.853	0.935	<.001	41	view →
THCA	OS	Median	II,III,IV	0.548	1.000	.003	40	view →
UVM	OS	Median	All	1.000	0.480	.006	40	view →
UCS	DFS	Median	II,III,IV	0.184	0.535	.004	34	view →
BLCA	DFS	Quartile	II,III,IV	0.650	0.449	.004	23	view →
LUAD	OS	Quartile	II,III,IV	0.603	0.380	.010	17	view →
CHOL	OS	Quartile	II,III,IV	0.088	0.689	.010	15	view →
DLBC	OS	Tertile	III,IV	0.084	1.000	.023	11	view →
LUSC	OS	Quartile	III,IV	0.451	0.789	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0070943–BRCA (DFS)

Open the BRCA breakdown →