Neutrophil-mediated killing of symbiont cell

Across TCGA cell cohorts, RNA activity of the Neutrophil-mediated killing of symbiont cell pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP94, CLEC12A, and PFN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil-mediated killing of symbiont cell activity versus CFAP94 in BLOOD_Leukemia (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFAP94 →	-0.189	-0.408	<.001	.002	3	3
BLOOD_Leukemia	CLEC12A →	+3.831	+1.087	.003	.005	3	3
BLOOD_Leukemia	PFN2 →	-1.446	-0.748	.007	.006	3	2
BLOOD_Leukemia	EPB41L3 →	+2.843	+0.717	.004	.009	3	2
BLOOD_Leukemia	LYZ →	+4.741	+0.754	.002	.006	3	2
BREAST	NRDE2 →	+0.625	+1.266	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070943 vs CFAP94 — BLOOD_Leukemia

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